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TAS-109

A DNA polymerase inhibitor
Catalog #: B3327
SKU-Size Size Price Qty
B3327-5 5 mg
$185.00
B3327-25 25 mg
$725.00
More Sizes Get Quote

Product Details

Alternate Name (2R,3S,4S,5R)-2-(4-amino-2-oxopyrimidin-1-yl)-4-hydroxy-5-(hydroxymethyl)oxolane-3-carbonitrile DFP-10917 TAS109 CNDAC
Appearance Solid
CAS # 2170136-65-7
Molecular Formula C₁₀H₁₂N₄O₄
Molecular Weight 252.23
Purity ≥98%
Solubility DMSO
SMILES N#C[[email protected]@H]1[[email protected]](N2C=CC(N)=NC2=O)O[[email protected]](CO)[[email protected]]1O
InChi InChI=1S/C10H12N4O4/c11-3-5-8(16)6(4-15)18-9(5)14-2-1-7(12)13-10(14)17/h1-2,5-6,8-9,15-16H,4H2,(H2,12,13,17)/t5-,6+,8-,9+/m0/s1
InChi Key DCYBPMFXJCWXNB-JWIUVKOKSA-N
PubChem CID 119184
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

TAS-109 is a novel deoxycitidine analog that inhibits DNA polymerase resulting in S-phase arrest, while prolonged exposure to TAS-109 at low concentration causes DNA fragmentation, G2/M phase arrest and apoptosis. TAS-109 displays activity in tumor xenografts resistant to other deoxycitidine analogs.


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