Call 408.493.1800 | Fax 408.493.1801 | Toll Free 800.891.9699 (US Only) | Email: [email protected]

TAPI-1

An inhibitor of TNF-α processing
Catalog #: 2068
$320.00

Product Details

Cat # +Size 2068-1
Size 1 mg
Alternate Name N-(R)-(2-(Hydroxyaminocarbonyl)methyl)-4-methylpentanoyl-L-naphthylalanyl-L-alanine amide; TNF protease inhibitor-0; C1
Appearance White solid
CAS # 171235-71-5
Molecular Formula C₂₆H₃₇N₅O₅
Molecular Weight 499.3
Purity ≥95% by HPLC
Solubility DMSO and MEOH
SMILES CC(C)CC(CC(=O)NO)C(=O)NC(CC1=CC2=CC=CC=C2C=C1)C(=O)NC(C)C(=O)NCCN
InChi InChI=1S/C26H37N5O5/c1-16(2)12-21(15-23(32)31-36)25(34)30-22(26(35)29-17(3)24(33)28-11-10-27)14-18-8-9-19-6-4-5-7-20(19)13-18/h4-9,13,16-17,21-22,36H,10-12,14-15,27H2,1-3H3,(H,28,33)(H,29,35)(H,30,34)(H,31,32)/t17-,21?,22-/m0/s1
InChi Key AWNBSWDIOCXWJW-OWHMDLSXSA-N
PubChem CID 9827273
Handling Protect from air and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Inhibitor of TNF-α processing (IC₅₀ = 100 nM), similar to TAPI-0 (Cat. No. 2067-1), but more stable in tissue culture and in vivo. Inhibits TACE and other metalloproteases. Blocks release of TNF- α (IC₅₀ = 50-100 μM), APP (1-8 μM), IL6R (5- 10 μM), TNFRI (5 -10 μM), TNFRII (25 -50 μM), and ObRa (leptin receptor), but not CSF-1, from cells in culture.


Why buy BioVision Products?
Innovation
Affordability
Global Presence
Technical Support
BioVision aims to provide our customers innovative tools for accelerating drug discovery and biological research. BioVision offers >8,000 products including the most comprehensive array of assay kits for key targets in Metabolic pathways.
BioVision is committed to providing the highest quality products at a competitive price.
We have a broad network of global distributors who are ready to address your research needs and ensure fast delivery.
Our highly trained Technical Support team provides comprehensive product support and is dedicated to resolving your issues quickly and efficiently.