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An inhibitor of TNF-α processing
Catalog #: 2067

Product Details

Cat # +Size 2067-1
Size 1 mg
Alternate Name N-(R)-(2-(Hydroxyaminocarbonyl)methyl)-4-methylpentanoyl-L-naphthylalanyl-L-alanine amide; TNF protease inhibitor-0; C1
Appearance White solid
CAS # 143457-40-3
Molecular Formula C₂₄H₃₂N₄O₅
Molecular Weight 456.55
Purity ≥95% by HPLC
Solubility DMSO (~ 5 mg/ml) or acetic acid (~ 5 mg/ml)
InChi InChI=1S/C24H32N4O5/c1-14(2)10-19(13-21(29)28-33)23(31)27-20(24(32)26-15(3)22(25)30)12-16-8-9-17-6-4-5-7-18(17)11-16/h4-9,11,14-15,19-20,33H,10,12-13H2,1-3H3,(H2,25,30)(H,26,32)(H,27,31)(H,28,29)/t15-,19?,20-/m0/s1
PubChem CID 3035404
MDL Number MFCD02684279
Handling Protect from air and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Inhibitor of TNF-α processing (IC₅₀ = 100 nM). Inhibits TACE (ADAM17) and other metalloproteases with Ki (nM) values of 8.8, 17, 6, 68, 0.5 and 0.2 for TACE, MDC9 (ADAM9), MMP-1, MMP-3, MMP-9 and MMP-13, respectively.

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