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A biologically active methoxyflavone
Catalog #: B3350
SKU-Size Size Price Qty
B3350-5 5 mg
B3350-25 25 mg
More Sizes Get Quote

Product Details

Alternate Name 5,6,7,8-tetramethoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one NSC 53909 NSC 618905 Ponkanetin
Appearance Solid
CAS # 481-53-8
Molecular Formula C₂₀H₂₀O₇
Molecular Weight 372.4
Purity ≥96% by HPLC
Solubility >10 mg/ml DMSO
InChi InChI=1S/C20H20O7/c1-22-12-8-6-11(7-9-12)14-10-13(21)15-16(23-2)18(24-3)20(26-5)19(25-4)17(15)27-14/h6-10H,1-5H3
PubChem CID 68077
MDL Number MFCD00017438
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Tangeretin is a methoxyflavone compound isolated from citrus fruits that demonstrates antiproliferative and antioxidant effects. It inhibits signaling in cancer cells, reducing ERK phosphorylation and growth of estradiol-stimulated T47D breast cancer cells (IC50 ~ 3 μM) and blocking p38 MAPK, JNK, and Akt activation in interleukin-1β-stimulated human lung carcinoma A549 cells. Tangeritin activates the pregnane X receptor, inducing MDR1 expression in human colonic LS180 cancer cells at a concentration of 10 μM. Recently, tangeretin has also been found to significantly reduce serum total and LDL cholesterol and triacylglycerols in hypercholesteremic hamsters.

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