TAME Hydrochloride

An anaphase-promoting complex/cyclosome (APC/C) inhibitor
Catalog #: 2050 | abID: ab141493

Product Details

abID ab141493
Alternate Name N-p-Tosyl-L-arginine methyl ester hydrochloride
Appearance White solid
CAS # 1784-03-8
Molecular Formula C₁₄H₂₂N₄O₄S.HCl
Molecular Weight 378.87
Purity ≥98% by TLC
Solubility Water (50 mg/ml)
InChi InChI=1S/C14H22N4O4S.ClH/c1-10-5-7-11(8-6-10)23(20,21)18-12(13(19)22-2)4-3-9-17-14(15)16;/h5-8,12,18H,3-4,9H2,1-2H3,(H4,15,16,17);1H
PubChem CID 3083734
MDL Number MFCD00012578
Handling Protect from air and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


A small molecule anaphase-promoting complex/cyclosome (APC/C) inhibitor that stabilizes APC/C substrates in mitotic Xenopus extracts. TAME binds to APC and prevents its activation by Cdc20 and Cdh1. In the absence of APC substrates, TAME ejects Cdc20 from the APC by promoting Cdc20 autoubiquitination in its N-terminal region. TAME also stabilizes cyclin B1 by prematurely terminating ubiquitination.

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