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TAK-733

A selective MEK1/2 inhibitor
Catalog #: 2460
SKU-Size Size Price Qty
2460-5 5 mg
$175.00
2460-25 25 mg
$695.00
More Sizes Get Quote

Product Details

Alternate Name (R)-3-(2,3-dihydroxypropyl)-6-fluoro-5-(2-fluoro-4-iodophenylamino)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione
Appearance Crystalline solid
CAS # 1035555-63-5
Molecular Formula C₁₇H₁₅F₂IN₄O₄
Molecular Weight 504.23
Purity ≥98% by HPLC
Solubility DMSO (>100 mg/ml)
SMILES CN1C2=C(C(=C(C1=O)F)NC3=C(C=C(C=C3)I)F)C(=O)N(C=N2)CC(CO)O
InChi InChI=1S/C17H15F2IN4O4/c1-23-15-12(16(27)24(7-21-15)5-9(26)6-25)14(13(19)17(23)28)22-11-3-2-8(20)4-10(11)18/h2-4,7,9,22,25-26H,5-6H2,1H3/t9-/m1/s1
InChi Key RCLQNICOARASSR-SECBINFHSA-N
PubChem CID 24963252
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A potent, selective, non-ATP competitive, allosteric MEK inhibitor. TAK-733 selectively binds to and inhibits the activity of MEK1/2, preventing the activation of MEK1/2-dependent effector proteins and transcription factors, which may result in the inhibition of growth factor-mediated cell signaling and tumor cell proliferation.


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