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TAK-632

A highly potent and selective pan-RAF inhibitor
Catalog #: 2473
SKU-Size Size Price Qty
2473-5 5 mg
$125.00
2473-25 25 mg
$485.00
More Sizes Get Quote

Product Details

Alternate Name N-(7-cyano-6-(4-fluoro-3-(2-(3-(trifluoromethyl)phenyl)acetamido)phenoxy)benzo[d]thiazol-2-yl)cyclopropanecarboxamide
Appearance White to off-white solid
CAS # 1228591-30-7
Molecular Formula C₂₇H₁₈F₄N₄O₃S
Molecular Weight 554.51
Purity ≥98% by HPLC
Solubility DMSO (>50 mg/ml)
SMILES O=C(NC1=C(F)C=CC(OC2=CC=C(N=C(NC(C3CC3)=O)S4)C4=C2C#N)=C1)CC5=CC(C(F)(F)F)=CC=C5
InChi InChI=1S/C27H18F4N4O3S/c28-19-7-6-17(12-21(19)33-23(36)11-14-2-1-3-16(10-14)27(29,30)31)38-22-InChI=1S/C27H18F4N4O3S/c28-19-7-6-17(12-21(19)33-23(36)11-14-2-1-3-16(10-14)27(29,30)31)38-22-9-8-20-24(18(22)13-32)39-26(34-20)35-25(37)15-4-5-15/h1-3,6-10,12,15H,4-5,11H2,(H,33,36)(H,34,35,37)
InChi Key OJFKUJDRGJSAQB-UHFFFAOYSA-N
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A selective pan-RAF inhibitor with IC₅₀ Values: 2.4 nM (BRAF V600E); 1.4 nM (C-RAF); 160 nM (VEGFR). TAK-632 displays significant cellular activity against mutated BRAF or mutated NRAS cancer cell lines.


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