TACE (TNF-α converting enzyme), human recombinant

Involved in the processing of TNF-α at the surface of cells
Catalog #: 7607 | abID: ab138784

Product Details

abID ab138784
Alternate Name Disintegrin and metalloproteinase domain-containing protein 17, ADAM 17, Snake venom-like protease, TNF-alpha convertase, TNF-alpha-converting enzyme
Gene Symbol ADAM17
Gene ID 6868
Accession # P78536
Source Insect cell
Appearance Lyophilized powder
Physical Form Description The untagged rh-TACE (TNF-alpha converting enzyme) is supplied as a lyophilized powder.
Molecular Weight 62 kDa
Biological Activity Activity of TACE was tested using the synthetic peptide, Abz-Leu-Ala-Gln-Ala-Val-Arg-Ser-Ser-Ser-Arg-Dpa(Dnp)-NH2, as a substrate.
Reconstitution Instructions With sterile deionized water at 0.1µg protein/µl.
Handling Centrifuge the vial prior to opening.
Storage Conditions -70°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

TACE (TNF-alpha converting enzyme, ADAM17) is a membrane-bound Metalloprotease from the ADAM (a disintegrin and Metalloprotease) family of proteins. It cleaves 26kDa type II membrane-bound precursor of TNF-a into 17 kDa mature form which is secreted. TACE is also known to process other membrane proteins including TNF receptor, TGF-alpha and amyloid protein precursor. Recombinant active untagged TACE amino acid sequence is from Arg215 to Asn651. The apparent molecular weight is bigger than the calculated MW due to the protein posttranslational modification in eukaryotic system.


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