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TA-01

A potent inhibitor of Casein kinase ε(CK1ε), casein kinase 1δ (CK1δ)and mitogen activated protein kinase(MAPK) p38α
Catalog #: B1214
SKU-Size Size Price Qty
B1214-5 5 mg
$125.00
B1214-25 25 mg
$475.00
More Sizes Get Quote

Product Details

Alternate Name 4-(2-(2,6-Difluorophenyl)-4-(fluorophenyl)-1H-imidazol-5-yl)pyridine
Appearance Beige Solid
CAS # 1784751-18-3
Molecular Formula C₂₀H₁₂F₃N₃
Molecular Weight 351.32
Purity ≥98% by HPLC
Solubility DMSO(>5 mg/ml)
SMILES C1=CC(=C(C(=C1)F)C2=NC(=C(N2)C3=CC=NC=C3)C4=CC=C(C=C4)F)F
InChi InChI=1S/C20H12F3N3/c21-14-6-4-12(5-7-14)18-19(13-8-10-24-11-9-13)26-20(25-18)17-15(22)2-1-3-16(17)23/h1-11H,(H,25,26)
InChi Key TWPJJJZCYVFUOA-UHFFFAOYSA-N
PubChem CID 91691129
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

TA-01 is a potential inhibitor of Casein kinase ε(CK1ε), casein kinase 1δ (CK1δ) and mitogen activated protein kinase(MAPK) p38α with IC₅₀ of 6.4, 6.8 and 6.7 nM, respectively. It shows complete inhibition of cardiogenesis at 5 μM showing reduced expression of mesoderm markers and the pre-cardiac marker Isl-1.


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