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SZL-P1-41

A selective Skp2 inhibitor
Catalog #: B3325
SKU-Size Size Price Qty
B3325-5 5 mg
$195.00
B3325-25 25 mg
$775.00
More Sizes Get Quote

Product Details

Alternate Name 3-(2-Benzothiazolyl)-6-ethyl-7-hydroxy-8-(1-piperidinylmethyl)-4H-1-benzopyran-4-one
Appearance Off-white solid
CAS # 1816294-67-3
Molecular Formula C₂₄H₂₄N₂O₃S
Molecular Weight 420.52
Purity ≥98% by HPLC
Solubility ~2 mg/ml DMSO
SMILES OC(C(CC)=C2)=C(CN3CCCCC3)C1=C2C(C(C4=NC5=C(C=CC=C5)S4)=CO1)=O
InChi InChI=1S/C24H24N2O3S/c1-2-15-12-16-22(28)18(24-25-19-8-4-5-9-20(19)30-24)14-29-23(16)17(21(15)27)13-26-10-6-3-7-11-26/h4-5,8-9,12,14,27H,2-3,6-7,10-11,13H2,1H3
InChi Key JKIXLEKBXHMXTN-UHFFFAOYSA-N
PubChem CID 1286902
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

SZL P1-41 is a specific Skp2 inhibitor that binds to the F-box domain of Skp2 to prevent Skp1 association and Skp2 SCF complex formation. Also inhibits Skp2-mediated p27 and Akt ubiquitination in vivo and in vitro. Suppresses the survival of cancer cells and cancer stem cells by triggering cell senescence and inhibiting glycolysis. Displays antitumor effects in multiple animal models and cancer cell lines.


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