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Syk Inhibitor

A potent and reversible Syk inhibitor
Catalog #: 1983
SKU-Size Size Price Qty
1983-1 1 mg
1983-5 5 mg
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Product Details

Alternate Name Spleen Tyrosine Kinase Inhibitor
Appearance Orange solid
CAS # 622387-85-3
Molecular Formula C₁₈H₁₅N₃O₃S
Molecular Weight 353.39
Purity ≥97% by HPLC (sum of two isomers)
Solubility DMSO
InChi InChI=1S/C18H15N3O3S/c1-21-10-11(13-4-2-3-5-17(13)21)8-15-14-9-12(25(19,23)24)6-7-16(14)20-18(15)22/h2-10H,1H3,(H,20,22)(H2,19,23,24)/b15-8-
PubChem CID 6419747
MDL Number MFCD07776820
Handling Protect from light and mositure
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Cell-permeable. An oxindole derivative that acts as a potent, reversible, and ATP-competitive Spleen tyrosine kinase (Syk) inhibitor (IC₅₀ = 14 nM). Has been shown to effectively inhibit FcεRI-mediated degranulation in the rat basophilic leukemia cell line, RBL-2H3 (EC₅₀ = 313 nM). Inhibits assembly of NLRP3 inflammasomes induced by Nigericin.

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