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SYK Inhibitor, R406

A potent SYK (Spleen Tyrosine Kinase) inhibitor
Catalog #: 9682
SKU-Size Size Price Qty
9682-5 5 mg
9682-25 25 mg
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Product Details

Alternate Name 6-((5-fluoro-2-((3,4,5-trimethoxyphenyl)amino)pyrimidin-4-yl)amino)-2,2-dimethyl-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one
Appearance Off-white solid
CAS # 841290-80-0
Molecular Formula C₂₂H₂₃FN₆O₅
Molecular Weight 470.45
Purity ≥98% by HPLC
Solubility DMSO (>5 mg/ml)
InChi InChI=1S/C22H23FN6O5/c1-22(2)20(30)28-19-13(34-22)6-7-16(27-19)26-18-12(23)10-24-21(29-18)25-11-8-14(31-3)17(33-5)15(9-11)32-4/h6-10H,1-5H3,(H3,24,25,26,27,28,29,30)
PubChem CID 11213558
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


R406 is a potent SYK (Spleen Tyrosine Kinase) inhibitor (IC₅₀ = 41 nM). R406 strongly inhibits SYK but not Lyn, and displays 5-fold less potency towards FLT3. R406 induces apoptosis in diffuse large B-cell lymphoma cell lines. It blocks B cell receptor signaling through inhibition of SYK autophosphorylation of Y525/Y526 and SYK-dependent phosphorylation of the B-cell linker protein.

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