Call 408.493.1800 | Fax 408.493.1801 | Toll Free 800.891.9699 (US Only) | Email: [email protected]

SW-044248

A potent and selective Topoisomerase I inhibitor.
Catalog #: B1135
SKU-Size Size Price Qty
B1135-5 5 mg
$135.00
B1135-25 25 mg
$535.00
More Sizes Get Quote

Product Details

Alternate Name 2-((5-ethyl-5H-[1,2,4]triazino[5,6-b]indol-3-yl)thio)-N-(2-methoxyphenyl)butanamide
Appearance Yellow Solid
CAS # 522650-83-5 
Molecular Formula C₂₂H₂₃N₅O₂S
Molecular Weight 421.51
Purity ≥98% by HPLC
Solubility DMSO (>40 mg/ml)
SMILES CCC(C(=O)NC1=CC=CC=C1OC)SC2=NC3=C(C4=CC=CC=C4N3CC)N=N2
InChi 1S/C22H23N5O2S/c1-4-18(21(28)23-15-11-7-9-13-17(15)29-3)30-22-24-20-19(25-26-22)14-10-6-8-12-16(14)27(20)5-2/h6-13,18H,4-5H2,1-3H3,(H,23,28)
InChi Key PEVRGVRHMMZNGI-UHFFFAOYSA-N
PubChem CID 3152990
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

SW-044248 is a selective Topoisomerase I inhibitor. It is extremely potent and selectively toxic to NSCLC killing ~15% of a 74 NSCLC cell lines. It was not toxic to immortalized human bronchial cell lines. The intense transcriptional response to SW-044248 in HCC4017 cells significantly correlates to topoisomerase-I inhibition and not topoisomerase-II.


Why buy BioVision Products?
Innovation
Affordability
Global Presence
Technical Support
BioVision aims to provide our customers innovative tools for accelerating drug discovery and biological research. BioVision offers >8,000 products including the most comprehensive array of assay kits for key targets in Metabolic pathways.
BioVision is committed to providing the highest quality products at a competitive price.
We have a broad network of global distributors who are ready to address your research needs and ensure fast delivery.
Our highly trained Technical Support team provides comprehensive product support and is dedicated to resolving your issues quickly and efficiently.