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A potent and selective Topoisomerase I inhibitor.
Catalog #: B1135
SKU-Size Size Price Qty
B1135-5 5 mg
B1135-25 25 mg
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Product Details

Alternate Name 2-((5-ethyl-5H-[1,2,4]triazino[5,6-b]indol-3-yl)thio)-N-(2-methoxyphenyl)butanamide
Appearance Yellow Solid
CAS # 522650-83-5 
Molecular Formula C₂₂H₂₃N₅O₂S
Molecular Weight 421.51
Purity ≥98% by HPLC
Solubility DMSO (>40 mg/ml)
InChi 1S/C22H23N5O2S/c1-4-18(21(28)23-15-11-7-9-13-17(15)29-3)30-22-24-20-19(25-26-22)14-10-6-8-12-16(14)27(20)5-2/h6-13,18H,4-5H2,1-3H3,(H,23,28)
PubChem CID 3152990
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


SW-044248 is a selective Topoisomerase I inhibitor. It is extremely potent and selectively toxic to NSCLC killing ~15% of a 74 NSCLC cell lines. It was not toxic to immortalized human bronchial cell lines. The intense transcriptional response to SW-044248 in HCC4017 cells significantly correlates to topoisomerase-I inhibition and not topoisomerase-II.

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