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Superoxide Dismutase 1 (SOD-1) Antibody

Polyclonal Antibody to detect SOD1 in human, mouse and rat samples
Catalog #: 6641
SKU-Size Size Price Qty
6641-30T 30 µg
$89.00
6641-100 100 μg
$245.00
More Sizes Get Quote

Product Details

Antibody Target SOD1
Alternate Name Superoxide Dismutase 1, SODC
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen Recombinant Human SOD1 (BV-M61)
Accession # P00441
Gene ID 6647
Appearance Colorless liquid
Concentration 0.5 mg/ml
Formulation In PBS pH 7.2, containing 30% glycerol, 0.5% BSA, 5 mM EDTA and 0.03% Proclin
Purification Affinity Purified Antibody
Species Reactivity Human, mouse, rat
Application Western blot
Positive Control Western Blot: 3T3 cell lysate, rat kidney lysate
Application & Usage Western blot: 1:200
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Superoxide Dismutase (SOD) is an oxidoreductase that catalyzes the reaction between superoxide anions and hydrogen to yield molecular oxygen and hydrogen peroxide. The enzyme protects the cell against dangerous levels of superoxide. It belongs to the Cu-Zn superoxide dismutase family. It binds copper and zinc ions. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occurring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene. SOD1 destroys radicals which are normally produced within the cells and which are toxic to biological systems. Defects in SOD1 are the cause of amyotrophic lateral sclerosis type 1 (ALS1). ALS1 is a familial form of amyotrophic lateral sclerosis, a neurodegenerative disorder affecting upper and lower motor neurons and resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of cases leading to familial forms.


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