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Sunitinib Malate (Sutent)

based on 1 citations in multiple journalsSunitinib Malate (Sutent)14.1 4
A CSF-1 receptor kinase inhibitor
Catalog #: 1611
SKU-Size Size Price Qty
1611-25 25 mg
$70.00
1611-100 100 mg
$155.00
1611-1000 1 g
$445.00
More Sizes Get Quote

Product Details

Alternate Name Sunitinib Maleate, SU-11248, Sutent, PHA-290940AD, PNU-290940AD
Appearance Yellow-orange powder
CAS # 341031-54-7
Molecular Formula C₂₂H₂₇FN₄O₂.C₄H₆O₅
Molecular Weight 532.56
Purity ≥99% by HPLC
Solubility DMSO (40 mg/ml)
SMILES CCN(CC)CCNC(=O)C1=C(NC(=C1C)C=C2C3=C(C=CC(=C3)F)NC2=O)C.C(C(C(=O)O)O)C(=O)O
InChi InChI=1S/C22H27FN4O2.C4H6O5/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28;5-2(4(8)9)1-3(6)7/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28);2,5H,1H2,(H,6,7)(H,8,9)/b17-12-;/t;2-/m.0/s1
InChi Key LBWFXVZLPYTWQI-IPOVEDGCSA-N
PubChem CID 6456015
MDL Number MFCD08282795
Handling Protect from air and moisture
Storage Conditions -20°C
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.

Details

Sunitinib is a potent inhibitor of CSF-1 receptor kinase in an enzyme assay, with an IC₅₀ of 7 nM, and inhibits receptor phosphorylation in a cellular assay with an IC₅₀ of 61 nM. Sunitinib inhibits SCF-induced phosphotyrosine levels on KIT (IC₅₀ = 1 - 10 nM) and reduced SCF-stimulated ERK1/2 phosphorylation with an IC₅₀ value consistent with that for inhibition of KIT phosphotyrosine levels. Sunitinib also inhibited SCF-stimulated proliferation in NCI-H526 cells (IC₅₀ = 2 nM).


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Iris Uribesalgo, Apelin inhibition prevents resistance and metastasis associated with anti‐angiogenic therapy. EMBO Mol Med., June 2019;  31267692.
Orogo et al., Accumulation of Mitochondrial DNA Mutations Disrupts Cardiac Progenitor Cell Function and Reduces Survival. J. Biol. Chem., Sep 2015; 290: 22061 - 22075.
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