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Sulfo-LC-SPDP

A water-soluble, amine and thiol (sulfhydryl) reactive heterobifunctional crosslinking reagent.
Catalog #: 2325
SKU-Size Size Price Qty
2325-50 50 mg
$355.00
2325-250 250 mg
$1,395.00
More Sizes Get Quote

Product Details

Alternate Name Sulfosuccinimidyl 6-(3'-[2-pyridyldithio]-propionamido)hexanoate
Appearance White to Off-white Solid
Molecular Formula C₁₈H₂₂O₈N₃S₃Na
Molecular Weight 527.57
Purity ≥90% by NMR
Solubility H₂O (~ 6 mg/ml)
SMILES O=C(CC1S(=O)(O[Na])=O)N(OC(CCCCCNC(CCSSC2=CN=CC=C2)=O)=O)C1=O
InChi InChI=1S/C18H23N3O8S3.Na/c22-15(7-10-30-31-13-5-4-8-19-12-13)20-9-3-1-2-6-17(24)29-21-16(23)11-14(18(21)25)32(26,27)28;/h4-5,8,12,14H,1-3,6-7,9-11H2,(H,20,22)(H,26,27,28);/q;+1/p-1
InChi Key JYGUAOMOEQATKJ-UHFFFAOYSA-M
PubChem CID
Handling Protect from moisture
Storage Conditions -20 ̊C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

KEY FEATURES:• Sulfo-LC-SPDP releases a byproduct, pyridine-2-thione after reacting with free sulfhydryl groups. By measuring the release of this byproduct at 343 nm, the reaction can be easily followed• Amine-reactive; the "long chain" Sulfo-LC-SPDP crosslinking reagent has a 15.7 Å spacer arm• More water-soluble than the corresponding LC-SPDP• Membrane-impermeable which enables crosslinking on cell surface• The cleavable spacer arm enables separation of cross-linked productsAPPLICATIONS:• Reversible crosslinking of proteins• N-hydroxysulfosuccinimide (Sulfo-NHS) ester that reacts with primary amines, as found in lysine side chains• Sulfo-LC-SPDP crosslinking molecule pyridinyldisulfide reacts with sulhydryls to yield a reversible disulfide bond.


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