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SU 6668

A potent and ATP-competitive inhibitor of PDGF, VEGF and FGF receptor tyrosine kinases
Catalog #: 1931
SKU-Size Size Price Qty
1931-5 5 mg
$145.00
1931-25 25 mg
$495.00
More Sizes Get Quote

Product Details

Alternate Name 5-[1,2-Dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-propanoic acid
Appearance Orange red solid
CAS # 252916-29-3
Molecular Formula C₁₈H₁₈N₂O₃
Molecular Weight 310.35
Purity ≥98%
Solubility DMSO (~100 mM)
SMILES CC1=C(NC(=C1CCC(=O)O)C)C=C2C3=CC=CC=C3NC2=O
InChi InChI=1S/C18H18N2O3/c1-10-12(7-8-17(21)22)11(2)19-16(10)9-14-13-5-3-4-6-15(13)20-18(14)23/h3-6,9,19H,7-8H2,1-2H3,(H,20,23)(H,21,22)/b14-9+
InChi Key NHFDRBXTEDBWCZ-NTEUORMPSA-N
PubChem CID 5995546
MDL Number MFCD00149792
Handling Protect from light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Cell-permeable. A potent and ATP-competitive inhibitor of PDGF, VEGF and FGF receptor tyrosine kinases (RTKs) with IC₅₀ values of 0.06, 2.43, 3.04 and > 100 μM at PDGFRβ, VEGFR2, FGFR1 and EGFR respectively. Acts as a potent antiangiogenic and antitumor agent.


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