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SU-6656

A potent and selective Src tyrosine kinase inhibitor
Catalog #: B2334

In stock

SKU-Size Size Price Qty
B2334-5 5 mg
$115.00
B2334-25 25 mg
$455.00
More Sizes Get Quote

Product Details

Alternate Name (Z)-2-hydroxy-N,N-dimethyl-3-((4,5,6,7-tetrahydro-1H-indol-2-yl)methylene)-3H-indole-5-sulfonamide
Appearance Orange brown solid
CAS # 330161-87-0
Molecular Formula C₁₉H₂₁N₃O₃S
Molecular Weight 371.45
Purity ≥98% by HPLC
Solubility >10 mg/ml (DMSO)
SMILES CN(C)S(=O)(=O)C1=CC2=C(C=C1)NC(=O)C2=CC3=CC4=C(N3)CCCC4
InChi InChI=1S/C19H21N3O3S/c1-22(2)26(24,25)14-7-8-18-15(11-14)16(19(23)21-18)10-13-9-12-5-3-4-6-17(12)20-13/h7-11,20H,3-6H2,1-2H3,(H,21,23)/b16-10-
InChi Key LOGJQOUIVKBFGH-YBEGLDIGSA-N
PubChem CID 5312137
MDL Number MFCD10565928
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

SU-6656 is a potent and selective inhibitor of Src kinases, Including Src, Yes, Lyn, and Fyn (IC50 = 280, 20, 130, 170 nM, respectively). In NIH 3T3 cells, SU-6656 inhibits PDGF-/Src-driven mitogenesis and PDGF-stimulated c-Myc induction. SU-6656 in combination with radiation decrease clonogenic survival of endothelial cells.


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