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SU-5402

A FGFR inhibitor
Catalog #: 1645
SKU-Size Size Price Qty
1645-05 500 µg
$195.00
1645-1 1 mg
$365.00
More Sizes Get Quote

Product Details

Alternate Name 2-[(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)methyl]-4-meth yl-1H-pyrrole-3-propanoic acid
Appearance Yellow solid
CAS # 215543-92-3
Molecular Formula C₁₇H₁₆N₂O₃
Molecular Weight 296.32
Purity ≥97% by HPLC
Solubility DMSO (100 mM) )
SMILES CC1=CNC(=C1CCC(=O)O)C=C2C3=CC=CC=C3NC2=O
InChi InChI=1S/C17H16N2O3/c1-10-9-18-15(11(10)6-7-16(20)21)8-13-12-4-2-3-5-14(12)19-17(13)22/h2-5,8-9,18H,6-7H2,1H3,(H,19,22)(H,20,21)/b13-8-
InChi Key JNDVEAXZWJIOKB-JYRVWZFOSA-N
PubChem CID 5289418
MDL Number MFCD08235144
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A potent and selective inhibitor of fibroblast growth factor receptor (FGFR) (IC₅₀ = 0.03 µM for FGFR1) and vascular endothelial growth factor receptors (VEGFR) (IC₅₀ = 0.02 µM for VEGFR2). In addition, integrin β4-induced differentiation of neural stem cells was attenuated by SU 5402.


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