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SU 3327

An inhibitor of JNK
Catalog #: B2923
SKU-Size Size Price Qty
B2923-5 5 mg
$125.00
B2923-25 25 mg
$495.00
More Sizes Get Quote

Product Details

Alternate Name 5-((5-nitrothiazol-2-yl)thio)-1,3,4-thiadiazol-2-amine; 5-[(5-nitro-1,3-thiazol-2-yl)sulfanyl]-1,3,4-thiadiazol-2-amine; JNK Inhibitor XIII; BDBM29315
Appearance Solid
CAS # 40045-50-9
Molecular Formula C₅H₃N₅O₂S₃
Molecular Weight 261.3
Purity 95%
Solubility 4 mg/ml in Ethanol
50 mg/ml in DMSO
SMILES C1=C(SC(=N1)SC2=NN=C(S2)N)[N+](=O)[O-]
InChi InChI=1S/C5H3N5O2S3/c6-3-8-9-5(14-3)15-4-7-1-2(13-4)10(11)12/h1H,(H2,6,8)
InChi Key NQQBNZBOOHHVQP-UHFFFAOYSA-N
PubChem CID 11837140
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

SU 3327 is a selective inhibitor of c-Jun N-terminal kinase (JNK). It shows an IC₅₀ of 0.7 μM in the kinase assay. It Inhibits the protein-protein interaction between JNK and JIP with an IC₅₀ of 239 nM. It inhibits TNF-α stimulated phosphorylation of c-Jun in cells with an EC₅₀ of 6.23 μM. It restores insulin sensitivity in a mouse model of type-2 diabetes.


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