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A potent VEGFR kinase inhibitor
Catalog #: 9491
SKU-Size Size Price Qty
9491-5 5 mg
9491-25 25 mg
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Product Details

Alternate Name 3-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-2H-indol-2-one; Semaxinib
Appearance Orange solid
CAS # 204005-46-9
Molecular Formula C₁₅H₁₄N₂O
Molecular Weight 238.28
Purity ≥98% by HPLC
Solubility DMSO (>20 mg/ml)
InChi InChI=1S/C15H14N2O/c1-9-7-10(2)16-14(9)8-12-11-5-3-4-6-13(11)17-15(12)18/h3-8,16H,1-2H3,(H,17,18)/b12-8-
PubChem CID 5329098
MDL Number MFCD01940922
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


SU-5416 is a potent tyrosine kinase inhibitor best known as an inhibitor of the vascular endothelial growth factor receptor (VEGFR-2; Flk-1/KDR). In addition to inhibiting VEGFR-2 (IC₅₀ = 1 μM), SU-5416 also inhibits PDGFR (IC₅₀ = 20 μM), c-Kit (IC₅₀ = 30 nM), RET (IC₅₀ = 170 nM), Flt-3 (IC₅₀ = 160 nM), ABL (IC₅₀ = 11 μM), and ALK (IC₅₀ = 1.2 μM).SU 5416 does not inhibit epidermal growth factor (EGFR) or fibroblast growth factor receptor (FGFR) tyrosine kinases (IC₅₀ > 100 μM). Acts as a suppressor of tumor vascularization, preventing the growth of multiple tumor types.

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