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Product Details
| Alternate Name | 5-((5-nitrothiazol-2-yl)thio)-1,3,4-thiadiazol-2-amine; 5-[(5-nitro-1,3-thiazol-2-yl)sulfanyl]-1,3,4-thiadiazol-2-amine; JNK Inhibitor XIII; BDBM29315 |
|---|---|
| Appearance | Solid |
| CAS # | 40045-50-9 |
| Molecular Formula | C₅H₃N₅O₂S₃ |
| Molecular Weight | 261.3 |
| Purity | 95% |
| Solubility | 4 mg/ml in Ethanol 50 mg/ml in DMSO |
| SMILES | C1=C(SC(=N1)SC2=NN=C(S2)N)[N+](=O)[O-] |
| InChi | InChI=1S/C5H3N5O2S3/c6-3-8-9-5(14-3)15-4-7-1-2(13-4)10(11)12/h1H,(H2,6,8) |
| InChi Key | NQQBNZBOOHHVQP-UHFFFAOYSA-N |
| PubChem CID | 11837140 |
| Handling | Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure. |
| Storage Conditions | -20ºC |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
SU 3327 is a selective inhibitor of c-Jun N-terminal kinase (JNK). It shows an IC₅₀ of 0.7 μM in the kinase assay. It Inhibits the protein-protein interaction between JNK and JIP with an IC₅₀ of 239 nM. It inhibits TNF-α stimulated phosphorylation of c-Jun in cells with an EC₅₀ of 6.23 μM. It restores insulin sensitivity in a mouse model of type-2 diabetes.
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