Stimulator of interferon genes (STING) is a cytosolic receptor that senses both exogenous and endogenous cytosolic cyclic dinucleotides (CDNs), activating TBK1/IRF3 (interferon regulatory factor 3), NF-κB (nuclear factor κB), and STAT6 signaling pathways to induce robust type I interferon and proinflammatory cytokine responses. STING is known to be a central mediator of innate immunity and has recently been the focus of intense research for the treatment of cancer and infectious diseases and as vaccine adjuvants. BioVision is pleased to offer STING ligands and inhibitors for your research in this area.
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