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STING Antagonist, H-151

A STING antagonist
Catalog #: B2395

In stock

SKU-Size Size Price Qty
B2395-5 5 mg
$115.00
B2395-25 25 mg
$425.00
More Sizes Get Quote

Product Details

Alternate Name H151, H-151, N-(4-Ethylphenyl)-N'-1H-indol-3-yl-urea
Appearance Off-white solid
CAS # 941987-60-6
Molecular Formula C₁₇H₁₇N₃O
Molecular Weight 279.34
Purity ≥98% by HPLC
Solubility >25 mg/ml in DMSO
SMILES CCC1=CC=C(C=C1)NC(=O)NC2=CNC3=CC=CC=C32
InChi InChI=1S/C17H17N3O/c1-2-12-7-9-13(10-8-12)19-17(21)20-16-11-18-15-6-4-3-5-14(15)16/h3-11,18H,2H2,1H3,(H2,19,20,21)
InChi Key UJZDIKVQFMCLBE-UHFFFAOYSA-N
PubChem CID 7616033
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

H-151 is a potent antagonist of the signaling molecule STING in mouse and human cells. It covalently binds to Cys91 of STING preventing activation via blockade of palmitoylation at Cys91. It reduces systemic cytokine response in mice treated with the STING agonist 10-carboxymethyl-9-acridanone and showed efficacy in Trex-/- mice.


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