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STF-62247

An autophagy inducer and an anticancer agent
Catalog #: B2210

In stock

SKU-Size Size Price Qty
B2210-5 5 mg
$115.00
B2210-25 25 mg
$455.00
More Sizes Get Quote

Product Details

Alternate Name N-(3-Methylphenyl)-4-(4-pyridinyl)-2-thiazolamine
Appearance Off-white solid
CAS # 315702-99-9
Molecular Formula C₁₅H₁₃N₃S
Molecular Weight 267.35
Purity ≥98% by HPLC
Solubility DMSO (>25 mg/ml)
SMILES CC1=CC(=CC=C1)NC2=NC(=CS2)C3=CC=NC=C3
InChi InChI=1S/C15H13N3S/c1-11-3-2-4-13(9-11)17-15-18-14(10-19-15)12-5-7-16-8-6-12/h2-10H,1H3,(H,17,18)
InChi Key KATNUHQNJGNLPW-UHFFFAOYSA-N
PubChem CID 704473
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

STF-62247 is a small molecule agonist that induces autophagy and selectively causes lethality in renal cell carcinoma (RCC) cells that have lost the von Hippel-Lindau (VHL) tumor suppressor activity (IC₅₀ = 625 nM). STF-62247 induces cytotoxicity and reduces tumor growth of VHL-deficient RCC cells compared to genetically matched cells with wild-type VHL.


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