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STF-31

A potent glucose transporter 1 (GLUT1) inhibitor
Catalog #: 9585
SKU-Size Size Price Qty
9585-5 5 mg
$115.00
9585-25 25 mg
$455.00
More Sizes Get Quote

Product Details

Alternate Name 4-[[[[4-(1,1-Dimethylethyl)phenyl]sulfonyl]amino]methyl]-N-3-pyridinylbenzamide
Appearance Pale yellow solid
CAS # 724741-75-7
Molecular Formula C₂₃H₂₅N₃O₃S
Molecular Weight 423.53
Purity ≥98% by HPLC
Solubility DMSO (>30mg/ml)
SMILES CC(C)(C)C1=CC=C(C=C1)S(=O)(=O)NCC2=CC=C(C=C2)C(=O)NC3=CN=CC=C3
InChi InChI=1S/C23H25N3O3S/c1-23(2,3)19-10-12-21(13-11-19)30(28,29)25-15-17-6-8-18(9-7-17)22(27)26-20-5-4-14-24-16-20/h4-14,16,25H,15H2,1-3H3,(H,26,27)
InChi Key NGQPRVWTFNBUHA-UHFFFAOYSA-N
PubChem CID 984333
MDL Number MFCD04153828
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

STF-31 is a potent glucose transporter 1 (GLUT1) inhibitor (IC₅₀ = ~ 1 µM). It induces necrosis in cancer cells that lack the von Hippel-Lindau tumor suppressor gene, which overexpress GLUT1. Recently, STF-31 has been shown to inhibit the enzyme activity of nicotinamide phosphoribosyltransferase (NAMPT) in biochemical assay in vitro.


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