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StemRegenin 1

A promoter of self-renewal of hematopoietic stem cells (HSCs)
Catalog #: 1967
SKU-Size Size Price Qty
1967-1 1 mg
$90.00
1967-5 5 mg
$285.00
More Sizes Get Quote

Product Details

Alternate Name 4-(2-((2-Benzo[b]thiphen-3-yl)-9-isopropyl-9H-purin-6-yl)amino)ethyl)phenol hydrochloride; SR1
Appearance White solid
Molecular Formula C₂₄H₂₃N₅OS.HCl
Molecular Weight 466
Purity ≥98% by HPLC
Solubility DMSO (~ 10 mM)
PubChem CID
Handling Protect from light and air
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A cell-permeable purine derivative that acts as an antagonist of aryl hydrocarbon receptor and promotes the self-renewal of hematopoietic stem cells (HSCs). Culture of HSCs with SR1 led to a 50-fold increase in cells expressing CD34 and a 17-fold increase in cells that retain the ability to engraft immunodeficient mice. In the absence of cytokines, StemRegenin 1 did not induce proliferation, and at concentrations above 1 µM, it inhibits proliferation.


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Giulia Schiroli, Precise Gene Editing Preserves Hematopoietic Stem Cell Function following Transient p53-Mediated DNA Damage Response. Cell Stem Cell; Apr 19; 30905619.
Carolina Petrillo, Cyclosporine H Overcomes Innate Immune Restrictions to Improve Lentiviral Transduction and Gene Editing In Human Hematopoietic Stem Cells. Cell Stem Cell,  Dec 2018; 30416070.
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