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StemRegenin 1, Free base

A promoter of self-renewal of hematopoietic stem cells (HSCs)
Catalog #: 2642
SKU-Size Size Price Qty
2642-1 1 mg
$75.00
2642-5 5 mg
$260.00
More Sizes Get Quote

Product Details

Alternate Name 4-(2-((2-Benzo[b]thiphen-3-yl)-9-isopropyl-9H-purin-6-yl)amino)ethyl)phenol; SR1
Appearance White solid
CAS # 1227633-49-9
Molecular Formula C₂₄H₂₃N₅OS
Molecular Weight 429.54
Purity ≥98% by HPLC
Solubility DMSO (~ 10 mg/ml)
SMILES CC(C)N1C=NC2=C1N=C(N=C2NCCC3=CC=C(C=C3)O)C4=CSC5=CC=CC=C54
InChi InChI=1S/C24H23N5OS/c1-15(2)29-14-26-21-23(25-12-11-16-7-9-17(30)10-8-16)27-22(28-24(21)29)19-13-31-20-6-4-3-5-18(19)20/h3-10,13-15,30H,11-12H2,1-2H3,(H,25,27,28)
InChi Key BGFHMYJZJZLMHW-UHFFFAOYSA-N
PubChem CID 46199207
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A cell-permeable purine derivative that acts as an antagonist of aryl hydrocarbon receptor and promotes the self-renewal of hematopoietic stem cells (HSCs). Culture of HSCs with SR1 led to a 50-fold increase in cells expressing CD34 and a 17-fold increase in cells that retain the ability to engraft immunodeficient mice. In the absence of cytokines, StemRegenin 1 did not induce proliferation, and at concentrations above 1 µM, it inhibits proliferation.


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