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Staurosporine

based on 2 citations in multiple journalsStaurosporine24.1 4
A protein kinase inhibitor
Catalog #: 1048
SKU-Size Size Price Qty
1048-01 100 µg
$105.00
1048-1 1 mg
$320.00
More Sizes Get Quote

Product Details

Alternate Name Antibiotic AM-2282
Appearance Pale yellow solid
CAS # 62996-74-1
Molecular Formula C₂₈H₂₆N₄O₃
Molecular Weight 466.53
Purity >99% by TLC
Solubility DMSO ( 25 mg/ml)
SMILES CC12C(C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)NC)OC
InChi InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m0/s1
InChi Key HKSZLNNOFSGOKW-HMWZOHBLSA-N
PubChem CID 451705
MDL Number MFCD00077402
Handling Protect from light and moisture
Storage Conditions 4°C
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.

Details

Potent inhibitor of protein kinase C and most other kinases, including tyrosine kinases. Inhibits topoisomerase II directly by blocking transfer of phosphodiester bonds from DNA to active site tyrosine. Induces apoptosis in CHO cells at 1 µM.


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Debnath et al., Hsp90 Inhibitors as New Leads To Target Parasitic Diarrheal Diseases. Antimicrob. Agents Chemother., Jul 2014; 58: 4138 - 4144.
Lin K-R et al. (2007) J. Biol. Chem. 282: 21962-21972.
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