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Stattic

A STAT3 inhibitor
Catalog #: 2625
SKU-Size Size Price Qty
2625-5 5 mg
$75.00
2625-25 25 mg
$295.00
More Sizes Get Quote

Product Details

Alternate Name 6-​Nitro-​1,​1-​dioxide-​benzo[b]thiophene; Stat3 Inhibitor V
Appearance Pale yellow solid
CAS # 19983-44-9
Molecular Formula C₈H₅NO₄S
Molecular Weight 211.19
Purity >98%
Solubility DMSO (~ 25 mg/ml)
SMILES C1=CC(=CC2=C1C=CS2(=O)=O)[N+](=O)[O-]
InChi InChI=1S/C8H5NO4S/c10-9(11)7-2-1-6-3-4-14(12,13)8(6)5-7/h1-5H
InChi Key ZRRGOUHITGRLBA-UHFFFAOYSA-N
PubChem CID 2779853
MDL Number MFCD00173799
Handling Protect from air and light
Storage Conditions -20 ̊C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Stattic is a small molecule that selectively inhibits STAT3 activation, dimerization, and nuclear translocation by preventing the binding of tyrosine-phosphorylated peptide motifs to the STAT3 SH2 domain (IC₅₀ = 5.1 μM at 37°C). Displays selectivity over STAT1, STAT5, c-Myc/Max, Jun/Jun and Lck. At 10 μM, stattic induces apoptosis in STAT3-dependent breast cancer (MDA-MB-231 and MDA-MB-435S) cell lines.


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