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Product Details
| Alternate Name | 6-Nitro-1,1-dioxide-benzo[b]thiophene; Stat3 Inhibitor V |
|---|---|
| Appearance | Pale yellow solid |
| CAS # | 19983-44-9 |
| Molecular Formula | C₈H₅NO₄S |
| Molecular Weight | 211.19 |
| Purity | >98% |
| Solubility | DMSO (~ 25 mg/ml) |
| SMILES | C1=CC(=CC2=C1C=CS2(=O)=O)[N+](=O)[O-] |
| InChi | InChI=1S/C8H5NO4S/c10-9(11)7-2-1-6-3-4-14(12,13)8(6)5-7/h1-5H |
| InChi Key | ZRRGOUHITGRLBA-UHFFFAOYSA-N |
| PubChem CID | 2779853 |
| MDL Number | MFCD00173799 |
| Handling | Protect from air and light |
| Storage Conditions | -20 ̊C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Stattic is a small molecule that selectively inhibits STAT3 activation, dimerization, and nuclear translocation by preventing the binding of tyrosine-phosphorylated peptide motifs to the STAT3 SH2 domain (IC₅₀ = 5.1 μM at 37°C). Displays selectivity over STAT1, STAT5, c-Myc/Max, Jun/Jun and Lck. At 10 μM, stattic induces apoptosis in STAT3-dependent breast cancer (MDA-MB-231 and MDA-MB-435S) cell lines.
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