Product Details
| Antibody Target | STAT6 |
|---|---|
| Host | Rabbit |
| Antibody Type | Polyclonal |
| Isotype | Rabbit IgG |
| Immunogen | Synthetic peptide surrounding amino acid 608 of rat Stat6 |
| Accession # | NP_001037715.1 |
| Gene ID | 362896 |
| Appearance | Colorless liquid |
| Concentration | 0.5 mg/ml |
| Formulation | 0.5 mg/ml affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS), pH 7.2 containing 30% glycerol, 0.5% BSA, 0.5 mM EDTA and 0.03% proclin |
| Purification | Affinity purified |
| Species Reactivity | Human, mouse, rat |
| Application | Western blot |
| Application & Usage | Western blotting (0.5-4 µg/ml). However, the optimal concentrations should be determined individually. The antibody recognizes the 119 kDa full length and the 65 kDa short form of Stat6 in samples from human, mouse, and rat origins. |
| Handling | The antibody solution should be gently mixed before use. |
| Storage Conditions | -20 °C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Membrane receptor signaling by various ligands induces activation of Jak kinases which then leads to tyrosine phosphorylation of the various Stat transcription factors. Stat1 and Stat2 are induced by IFN-α and form a heterodimer which is part of the ISGF3 transcription factor complex. Althoμgh early reports indicate Stat3 activation by EGF and IL-6, it has been shown that Stat3β appears to be activated by both while Stat3α is activated by EGF, but not by IL-6. Highest expression of Stat4 is seen in testis and myeloid cells. IL-12 has been identified as an activator of Stat4. Stat5 is activated by prolactin and by IL-3. Stat6 is involved in IL-4 activated signaling pathways.
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