Stat5 Inhibitor

A Stat5 inhibitor
Catalog #: 9484 | abID:

Product Details

Alternate Name (E)-N'-((4-oxo-4H-chromen-3-yl)methylene)nicotinohydrazide
Appearance White solid
CAS # 285986-31-4
Molecular Formula C₁₆H₁₁N₃O₃
Molecular Weight 293.3
Purity ≥98% by HPLC
Solubility DMSO (10 mg/ml)
InChi InChI=1S/C16H11N3O3/c20-15-12(10-22-14-6-2-1-5-13(14)15)9-18-19-16(21)11-4-3-7-17-8-11/h1-10H,(H,19,21)
PubChem CID 2726045
MDL Number MFCD00124694
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


STAT5 Inhibitor suppresses STAT5 by targeting its SH2 domain (IC₅₀ = 47 µM against STAT5β SH2 domain EPO peptide binding activity). Comparatively, this compound displays reduced potency towards inhibiting the SH2 domain of STAT1, STAT3, or Lck (IC₅₀ > 500 µM). STAT5 Inhibitor has been shown to block STAT5/STAT5 DNA binding in K562 nuclear extracts. Cell-permeable.

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