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Stat3 Inhibitor I, S3I-201

A Stat3 Inhibitor
Catalog #: 1775
SKU-Size Size Price Qty
1775-5 5 mg
1775-25 25 mg
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Product Details

Alternate Name 2-Hydroxy-4-[[[[4-methylphenyl)sulfonyl]oxy]acetyl]amino]-benzoic acid; NSC 74859; S3I-201
Appearance Off-white solid
CAS # 501919-59-1
Molecular Formula C₁₆H₁₅NO₇S
Molecular Weight 365.36
Purity ≥97% by HPLC
Solubility DMSO (10 mg/ml)
InChi InChI=1S/C16H15NO7S/c1-10-2-5-12(6-3-10)25(22,23)24-9-15(19)17-11-4-7-13(16(20)21)14(18)8-11/h2-8,18H,9H2,1H3,(H,17,19)(H,20,21)
PubChem CID 252682
MDL Number MFCD09907564
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Inhibits Stat3.Stat3 complex formation and Stat3-DNA binding activity in vitro (IC₅₀ = 86 ± 33 µM) and Stat3-dependent transcriptional activities. S3I-201 inhibits the expression of the Stat3-regulated genes encoding cyclin D1, Bcl-xL, and survivin and inhibits the growth of human breast tumors in vivo.

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Jain, Rekha et al. (2017) Proteomic level changes associated with S3I201 treated U87 glioma cells, J Proteomics. 2017 Jan 6;150:341-350.
Wang, WJ et al., (2017) , Inhibition of the EGFR/STAT3/CEBPD Axis Reverses Cisplatin Cross-resistance with Paclitaxel in the Urothelial Carcinoma of the Urinary Bladder, Clin Cancer Res, 2017, 15;23(2):503-513
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