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STA-21

A STAT3 inhibitor
Catalog #: 2626
SKU-Size Size Price Qty
2626-250 250 µg
$125.00
2626-1000 1 mg
$475.00
More Sizes Get Quote

Product Details

Alternate Name ((3S)-​3,​4-​dihydro-​8-​hydroxy-​3-​methyl-​benz[a]anthracene-​1,​7,​12(2H)-​trione; Ochromycinone
Appearance Light orange solid
CAS # 28882-53-3
Molecular Formula C₁₉H₁₄O₄
Molecular Weight 306.31
Purity >98%
Solubility DMSO (~ 15 mg/ml)
SMILES CC1CC2=C(C(=O)C1)C3=C(C=C2)C(=O)C4=C(C3=O)C=CC=C4O
InChi InChI=1S/C19H14O4/c1-9-7-10-5-6-12-17(15(10)14(21)8-9)19(23)11-3-2-4-13(20)16(11)18(12)22/h2-6,9,20H,7-8H2,1H3/t9-/m0/s1
InChi Key ZAWXOCUFQSQDJS-VIFPVBQESA-N
PubChem CID 11808929
Handling Protect from air and light
Storage Conditions -20 ̊C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

STA-21 is a natural antibiotic that acts as a selective STAT3 inhibitor. It inhibits STAT3 by preventing its dimerization and DNA binding when used at concentrations of 20-30 μM. It blocks the growth and survival of cancer cells that express constitutively active STAT3 (e.g., DU145 cells, IC₅₀ = 12.2 μM). It reciprocally regulates Th17 and Treg cells, and inhibits osteoclast formation.


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