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SSE-15206

A microtubule depolymerizing agent
Catalog #: B2342

In stock

SKU-Size Size Price Qty
B2342-5 5 mg
$115.00
B2342-25 25 mg
$455.00
More Sizes Get Quote

Product Details

Alternate Name 4,5-Dihydro-3-phenyl-5-(3,4,5-trimethoxyphenyl)-1H-pyrazole-1-carbothioamide,SSE15206
Appearance Crystalline solid
CAS # 1370046-40-4
Molecular Formula C₁₉H₂₁N₃O₃S
Molecular Weight 371.46
Purity ≥98% by HPLC
Solubility DMSO
SMILES COC1=CC(=CC(=C1OC)OC)C2CC(=NN2C(=S)N)C3=CC=CC=C3
InChi InChI=1S/C19H21N3O3S/c1-23-16-9-13(10-17(24-2)18(16)25-3)15-11-14(21-22(15)19(20)26)12-7-5-4-6-8-12/h4-10,15H,11H2,1-3H3,(H2,20,26)
InChi Key GONIBFCARADPAC-UHFFFAOYSA-N
PubChem CID 56944939
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

SSE-15206 is a pyrazolinethioamide derivative that has potent antiproliferative activities in cancer cell lines of different origins and overcomes resistance to microtubule-targeting agents. Treatment of cells with SSE-15206 causes aberrant mitosis resulting in G2/M arrest due to incomplete spindle formation, a phenotype often associated with drugs that interfere with microtubule dynamics. SSE15206 inhibits microtubule polymerization both in biochemical and cellular assays by binding to colchicine site in tubulin as shown by docking and competition studies.


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