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SSB IgG (Human) ELISA Kit

An ELISA kit for quantitative measurement of SSB IgG in human serum and plasma samples

WARNING:
This product can expose you to chemicals including Sulfuric acid and TMB, which are known to the State of California
to cause cancer. For more information go to www.P65Warnings.ca.gov.
Catalog #: E4978
$695.00

Product Details

Cat # +Size E4978-100
Size 96 assays
Detection Method Absorbance (450 nm)
Species Reactivity Human
Features & Benefits ● No significant cross-reactivity or interference with other autoantibodies was observed
● Easy, convenient and time-saving method to measure the amount of SSB IgG in serum and plasma samples
Kit Components ● Micro ELISA plate coated with SSB antigen
● Sample Diluent
● Calibrator
● Positive Control
● Negative Control
● Enzyme conjugate
● TMB Substrate
● Wash Buffer (20X)
● Stop Solution
Storage Conditions 4ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Sjogren syndrome (SS)B/La are autoantigens that are a type of extractable nuclear antigen (ENA). They are 48 kDa proteins that are associated with RNA polymerase III newly synthesized products. Studies have demonstrated that SSB/La plays a role in the initiation and termination of RNA Polymerase III transcription. SSB/La binds to the polypyrimidine tracts at the 3’ end of the transcripts via RNA Polymerase III termination signal and stabilizes these tracts. SSB/La autoantibodies are commonly detected in the sera of patients suffering from systemic lupus erythematosus (SLE) and Sjögren's syndrome. BioVision’s SSB IgG (Human) ELISA kit quantitatively measures SSB IgG antibodies in human serum and plasma samples. Samples, calibrator, and controls are added to the wells pre-coated with SSB antigen. IgG antibodies to SSB, if present in the samples, will bind to the SSB antigen. The wells are then washed with Wash Buffer, followed by incubation with the enzyme conjugate. After incubation, any unattached conjugates are washed off by Wash Buffer. The enzymatic reaction is detected by the addition of TMB-substrate. Finally, the reaction is terminated with an acidic stop solution. The color developed is directly proportional to the amount of IgG antibodies to SSB present in the sample.


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