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SRPIN340

A SRPK inhibitor
Catalog #: 2458
SKU-Size Size Price Qty
2458-5 5 mg
$115.00
2458-25 25 mg
$455.00
More Sizes Get Quote

Product Details

Alternate Name N-[2-(1-piperidinyl)-5-(trifluoromethyl)phenyl]isonicotinamide; SRPK Inhibitor
Appearance Light yellow solid
CAS # 218156-96-8
Molecular Formula C₁₈H₁₈F₃N₃O
Molecular Weight 349.35
Purity ≥98% by HPLC
Solubility DMSO (~100 mg/ml)
SMILES O=C(C1=CC=NC=C1)NC2=CC(C(F)(F)F)=CC=C2N3CCCCC3
InChi InChI=1S/C18H18F3N3O/c19-18(20,21)14-4-5-16(24-10-2-1-3-11-24)15(12-14)23-17(25)13-6-8-22-9-7-13/h4-9,12H,1-3,10-11H2,(H,23,25)
InChi Key DWFGGOFPIISJIT-UHFFFAOYSA-N
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

An ATP-competitive, serine/arginine-rich protein kinase (SRPK)-specific inhibitor (Ki = 0.89 µM for SRPK1). SRPIN 340 does not inhibit other classes of Serine-Arginine-Rich Protein Kinases (SRPKs) significantly, including Clk1 and Clk4 and >140 other SR kinases. SRPIN340 also suppresses VEGF expression and attenuates choroidal neovascularization (CNV).


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