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A REV-ERB agonist
Catalog #: B1210
SKU-Size Size Price Qty
B1210-10 10 mg
B1210-50 50 mg
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Product Details

Alternate Name Ethyl 3-[[[(4-chlorophenyl)methyl][(5-nitro-2-thienyl)methyl]amino]methyl]-1-pyrrolidinecarboxylate
Appearance Off White solid
CAS # 1379686-30-2
Molecular Formula C₂₀H₂₄ClN₃O₄S
Molecular Weight 437.94
Purity ≥98% by HPLC
Solubility DMSO(>40 mg/ml)
InChi InChI=1S/C20H24ClN3O4S/c1-2-28-20(25)23-10-9-16(13-23)12-22(11-15-3-5-17(21)6-4-15)14-18-7-8-19(29-18)24(26)27/h3-8,16H,2,9-14H2,1H3
PubChem CID 57394020
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


SR9009 is a REV-ERB agonist that increases the constitutive repression of genes regulated by REV-ERB α (IC50=670 nM) and REV-ERBβ (IC50 = 800 nM). SR9009 decreases the circadian locomotor activity during dark phase through activation of REV-ERB, altering the expression pattern of core clock genes in the hypothalamai of mice. In in vivo experiments SR9009 has shown to decrease body fat and improved dyslipidemia and hyperglycemia.

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