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SR-717 Lithium

A non-nucleotide STING agonist
Catalog #: B3216
SKU-Size Size Price Qty
B3216-5 5 mg
$135.00
B3216-25 25 mg
$535.00
More Sizes Get Quote

Product Details

Alternate Name SR717; lithium 2-(6-(1H-imidazol-1-yl)pyridazine-3-carboxamido)-4,5-difluorobenzoate
Peptide Sequence N/A
Appearance Crystalline solid
CAS # 2375421-09-1
Molecular Formula C₁₅H₈F₂LiN₅O₃
Molecular Weight 351.19
Purity ≥98%
SMILES [Li+].C1=CC(=NN=C1C(=O)NC2=CC(=C(C=C2C(=O)[O-])F)F)N3C=CN=C3
InChi InChI=1S/C15H9F2N5O3.Li/c16-9-5-8(15(24)25)12(6-10(9)17)19-14(23)11-1-2-13(21-20-11)22-4-3-18-7-22;/h1-7H,(H,19,23)(H,24,25);/q;+1/p-1
InChi Key ODSAJRWPLSVEHJ-UHFFFAOYSA-M
PubChem CID 139434658
MDL Number >10 mg/ml DMSO
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

SR-717 is a non-nucleotide STING (stimulator of interferon (IFN) genes) agonist with EC50s of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines, respectively. SR-717 is a stable cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) mimetic. Displays antitumor activity.


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