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SR-4370

A potent histone deacetylase 3 (HDAC3) inhibitor
Catalog #: B3324
SKU-Size Size Price Qty
B3324-5 5 mg
$115.00
B3324-25 25 mg
$455.00
More Sizes Get Quote

Product Details

Alternate Name 2',3'-difluoro-[1,1'-biphenyl]-4-carboxylic acid, 2-butylhydrazide SR4370
Appearance Crystalline solid
CAS # 1816294-67-3
Molecular Formula C₁₇H₁₈F₂N₂O
Molecular Weight 304.33
Purity ≥98%
Solubility >50 mg/ml DMSO
SMILES FC1=CC=CC(C2=CC=C(C(NNCCCC)=O)C=C2)=C1F
InChi InChI=1S/C17H18F2N2O/c1-2-3-11-20-21-17(22)13-9-7-12(8-10-13)14-5-4-6-15(18)16(14)19/h4-10,20H,2-3,11H2,1H3,(H,21,22)
InChi Key OSQKWTZHYXRTBG-UHFFFAOYSA-N
PubChem CID 118418385
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

SR-4370 is a potent and selective inhibitor of histone deacetylase 3 (HDAC3; IC50 = 6 nM). It displays selectivity for HDAC3 over HDAC1, -2, -6, and -8 (IC50s = 0.13, 0.58, 3.7, and 2.3 µM, respectively). SR-4370 suppresses AR signaling and in vivo prostate tumor growth.


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