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SR-144528

A cannabinoid (CB) receptor 2 inverse agonist
Catalog #: B2615
SKU-Size Size Price Qty
B2615-5 5 mg
$175.00
B2615-25 25 mg
$695.00
More Sizes Get Quote

Product Details

Alternate Name SR144528, 5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-N-[(1S,2S,4R)-1,3,3-trimethylbicyclo[2.2.1]hept-2-yl]-1H-pyrazole-3-carboxamide
Appearance White solid
CAS # 192703-06-3
Molecular Formula C₂₉H₃₄ClN₃O
Molecular Weight 476.05
Purity ≥98%
Solubility >40 mg/ml in DMSO, >40 mg/ml in Ethanol
SMILES CC1=CC=C(C=C1)CN2C(=CC(=N2)C(=O)NC3C(C4CCC3(C4)C)(C)C)C5=CC(=C(C=C5)Cl)C
InChi InChI=1S/C29H34ClN3O/c1-18-6-8-20(9-7-18)17-33-25(21-10-11-23(30)19(2)14-21)15-24(32-33)26(34)31-27-28(3,4)22-12-13-29(27,5)16-22/h6-11,14-15,22,27H,12-13,16-17H2,1-5H3,(H,31,34)/t22-,27-,29+/m1/s1
InChi Key SUGVYNSRNKFXQM-XRHWURSXSA-N
PubChem CID 3081355
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

SR-144528 is a cannabinoid (CB) receptor 2 inverse agonist (Ki values ranging from 0.3 to 5.6 nM). Displays >700-fold selectivity for CB2 over CB1 receptors. Blocks the effects of CP-55,940 on forskolin-sensitive adenylyl cyclase activity and MAPK in CHO cells expressing CB2 receptors. Also blocks CP 55,940-induced B-cell activation.


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