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A potent inhibitor of serine/arginine-rich protein kinase 1 (SRPK1) inhibitor
Catalog #: B2516
SKU-Size Size Price Qty
B2516-5 5 mg
B2516-25 25 mg
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Product Details

Alternate Name SPHINX-31; 5-(4-pyridinyl)-N-[2-[4-(2-pyridinylmethyl)-1-piperazinyl]-5-(trifluoromethyl)phenyl]-2-furancarboxamide
Appearance Crystalline solid
CAS # 1818389-84-2
Molecular Formula C₂₇H₂₄F₃N₅O₂
Molecular Weight 507.52
Purity ≥98% by HPLC
InChi InChI=1S/C27H24F3N5O2/c28-27(29,30)20-4-5-23(35-15-13-34(14-16-35)18-21-3-1-2-10-32-21)22(17-20)33-26(36)25-7-6-24(37-25)19-8-11-31-12-9-19/h1-12,17H,13-16,18H2,(H,33,36)
PubChem CID 1972002
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


SPHINX31 is a potent inhibitor of serine/arginine-rich protein kinase 1 (SRPK1) IC₅₀ = 5.9 nM). It displays selectivity for SRPK1 over a panel of 50 kinases at a concentration of 1 μM. SPHINX31 inhibits phosphorylation of serine/arginine-rich splicing factor 1 (SRSF1), an SRPK1 substrate, in PC3 cells (EC50 = 360 nM) and increases expression of the anti-angiogenic VEGF-A165b splice variant in retinal pigment epithelial (RPE) cells.

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