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SPDP Crosslinker

A cleavable heterobifunctional crosslinker.
Catalog #: 2328
SKU-Size Size Price Qty
2328-50 50 mg
2328-250 250 mg
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Product Details

Alternate Name N-succinimidyl-3-(2-pyridyldithio)propionate; 3-(2-Pyridyldithio)propionic acid N-hydroxysuccinimide ester; 3-(2-Pyridyldithio)propionic acid NHS ester
Appearance White to Off-white Solid
CAS # 68181-17-9
Molecular Formula C₁₂H₁₂N₂O₁₀
Molecular Weight 312.36
Purity ≥90% by NMR
Solubility DMSO or DMF
InChi InChI=1S/C12H12N2O4S2/c15-10-4-5-11(16)14(10)18-12(17)6-8-19-20-9-3-1-2-7-13-9/h1-3,7H,4-6,8H2
PubChem CID 100682
MDL Number MFCD00009636
Handling Protect from moisture
Storage Conditions -20 ̊C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


KEY FEATURES:• SPDP contains a dithiopyridyl group which is reactive towards cysteines (-SH groups) and an NHS group, which is useful when targeting primary amines (-NH2 groups)• SPDP releases a byproduct, pyridine-2-thione after reacting with free sulfhydryl groups. By measuring the release of this byproduct at 343 nm, the reaction can be easily followed• Contains a disulfide linkage in its spacer arm with a length of 6.8 Å• The spacer is cleavable with reducing agent, such as DTT, TCEP, etc.APPLICATIONS:• Reversible crosslinking of proteins• N-hydroxysulfosuccinimide (Sulfo-NHS) ester that reacts with primary amines, as found in lysine side chains• Useful for adding sulfhydryl groups to proteins by attachment to lysine residues• Useful for preparation of enzyme immunoconjugates and hapten carrier molecule conjugates

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