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Product Details
| Cat # +Size | 1669-5 |
|---|---|
| Size | 5 mg |
| Alternate Name | Anthra[1-9-cd]pyrazol-6(2H)-one |
| Appearance | Off-white solid |
| CAS # | 129-56-6 |
| Molecular Formula | C₁₄H₈N₂O |
| Molecular Weight | 220.23 |
| Purity | ≥98% by HPLC |
| Solubility | DMSO (100 mM) or EtOH (10 mM) |
| SMILES | C1=CC=C2C(=C1)C3=NNC4=CC=CC(=C43)C2=O |
| InChi | InChI=1S/C14H8N2O/c17-14-9-5-2-1-4-8(9)13-12-10(14)6-3-7-11(12)15-16-13/h1-7H,(H,15,16) |
| InChi Key | ACPOUJIDANTYHO-UHFFFAOYSA-N |
| PubChem CID | 8515 |
| MDL Number | MFCD00022289 |
| Handling | Protect from air and light |
| Storage Conditions | 4°C |
| Shipping Conditions | RT |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Cell-permeable. A selective inhibitor of c-Jun N-terminal kinase (JNK). Competitively and reversibly inhibits JNK1, 2 and 3 (IC₅₀ = 40-90 nM) with negligible activity at ERK2, p38β and a range of enzymes (IC₅₀ > 10 µM).
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Hung, Tung-Wei et al. (2016) Pentraxin 3 Activates JNK Signaling and Regulates the Epithelial-To-Mesenchymal Transition in Renal Fibrosis, Cell Physiol Biochem. 2016;40(5):1029-1038.
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