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SP600125

A JNK inhibitor
Catalog #: 1669
$85.00

Product Details

Cat # +Size 1669-5
Size 5 mg
Alternate Name Anthra[1-9-cd]pyrazol-6(2H)-one
Appearance Off-white solid
CAS # 129-56-6
Molecular Formula C₁₄H₈N₂O
Molecular Weight 220.23
Purity ≥98% by HPLC
Solubility DMSO (100 mM) or EtOH (10 mM)
SMILES C1=CC=C2C(=C1)C3=NNC4=CC=CC(=C43)C2=O
InChi InChI=1S/C14H8N2O/c17-14-9-5-2-1-4-8(9)13-12-10(14)6-3-7-11(12)15-16-13/h1-7H,(H,15,16)
InChi Key ACPOUJIDANTYHO-UHFFFAOYSA-N
PubChem CID 8515
MDL Number MFCD00022289
Handling Protect from air and light
Storage Conditions 4°C
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.

Details

Cell-permeable. A selective inhibitor of c-Jun N-terminal kinase (JNK). Competitively and reversibly inhibits JNK1, 2 and 3 (IC₅₀ = 40-90 nM) with negligible activity at ERK2, p38β and a range of enzymes (IC₅₀ > 10 µM).


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Hung, Tung-Wei et al. (2016) Pentraxin 3 Activates JNK Signaling and Regulates the Epithelial-To-Mesenchymal Transition in Renal Fibrosis, Cell Physiol Biochem. 2016;40(5):1029-1038.
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