A reversible inhibitor of Lysine-specific demethylase (LSD1)
Catalog #: 9446 | abID:

Product Details

Alternate Name 3-​(4-​morpholinylsulfonyl)-​benzoic acid (2E)-​2-​[1-​(5-​chloro-​2-​hydroxyphenyl)ethylidene]hydrazide
Appearance Off-white solid
CAS # 1423715-09-6
Molecular Formula C₁₉H₂₀ClN₃O₅S
Molecular Weight 437.9
Purity ≥98% by HPLC
Solubility DMSO (~25 mg/ml)
InChi InChI=1S/C19H20ClN3O5S/c1-13(17-12-15(20)5-6-18(17)24)21-22-19(25)14-3-2-4-16(11-14)29(26,27)23-7-9-28-10-8-23/h2-6,11-12,21H,7-10H2,1H3,(H,22,25)/b17-13-
PubChem CID 71494974
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


SP-2509 is a reversible inhibitor of Lysine-specific demethylase (LSD1) (IC₅₀ = 13 nM). It has no effect on monoamine oxidases A and B. SP2509 attenuates the binding of LSD1 to CoREST, allowing increased methylation of H3K4 and driving increased expression of p21, p27, and CCAAT/enhancer binding protein α in cultured acute myeloid leukemia (AML) cells.

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