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Sotrastaurin

A potent and orally-active pan-PKC inhibitor
Catalog #: B2795
SKU-Size Size Price Qty
B2795-1 1 mg
$65.00
B2795-5 5 mg
$225.00
More Sizes Get Quote

Product Details

Alternate Name 3-(1H-indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione; AEB07
Peptide Sequence N/A
Appearance Crystalline solid
CAS # 425637-18-9
Molecular Formula C₂₅H₂₂N₆O₂
Molecular Weight 438.48
Purity ≥98% by HPLC
Solubility >50 mg/ml DMSO
SMILES CN1CCN(CC1)C2=NC3=CC=CC=C3C(=N2)C4=C(C(=O)NC4=O)C5=CNC6=CC=CC=C65
InChi InChI=1S/C25H22N6O2/c1-30-10-12-31(13-11-30)25-27-19-9-5-3-7-16(19)22(28-25)21-20(23(32)29-24(21)33)17-14-26-18-8-4-2-6-15(17)18/h2-9,14,26H,10-13H2,1H3,(H,29,32,33)
InChi Key OAVGBZOFDPFGPJ-UHFFFAOYSA-N
PubChem CID 10296883
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Sotrastaurin (AEB071) is a potent pan-PKC (Protein Kinase C) inhibitor, with Kis of 0.22 nM, 0.64 nM, 0.95 nM, 1.8 nM, 2.1 nM and 3.2 nM for PKCθ, PKCβ, PKCα, PKCη, PKCδ and PKCε, respectively.


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