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Solithromycin

A "fourth-generation" macrolide antibiotic
Catalog #: B1222
SKU-Size Size Price Qty
B1222-5 5 mg
$165.00
B1222-25 25 mg
$650.00
More Sizes Get Quote

Product Details

Alternate Name (3aS,4R,7R,9R,10R,11R,13R,15S,15aR)-1-(4-(4-(3-aminophenyl)-1H-1,2,3-triazol-1-yl)butyl)-10-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4-ethyl-7-fluoro-11-methoxy-3a,7,9,11,13,15-hexamethyloctahydro-1H-[1]oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(7H,9H)-tetraone; CEM101
Appearance White to off-white solid
CAS # 760981-83-7
Molecular Formula C₄₃H₆₅FN₆O₁₀ 
Molecular Weight 845.01
Purity ≥98% by HPLC
Solubility DMSO
SMILES CCC1C2(C(C(C(=O)C(CC(C(C(C(=O)C(C(=O)O1)(C)F)C)OC3C(C(CC(O3)C)N(C)C)O)(C)OC)C)C)N(C(=O)O2)CCCCN4C=C(N=N4)C5=CC(=CC=C5)N)C
InChi InChI=1S/C43H65FN6O10/c1-12-32-43(8)35(50(40(55)60-43)19-14-13-18-49-23-30(46-47-49)28-16-15-17-29(45)21-28)26(4)33(51)24(2)22-41(6,56-11)37(27(5)36(53)42(7,44)39(54)58-32)59-38-34(52)31(48(9)10)20-25(3)57-38/h15-17,21,23-27,31-32,34-35,37-38,52H,12-14,18-20,22,45H2,1-11H3/t24-,25-,26+,27+,31+,32-,34-,35-,37-,38+,41-,42+,43-/m1/s1
InChi Key IXXFZUPTQVDPPK-ZAWHAJPISA-N
PubChem CID 25242512
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Solithromycin (CEM-101) is a "fourth-generation" macrolide antibiotic, that has three binding sites and is acid stable. The three binding sites confer activity against bacteria resistant to the older macrolides and ketolides. Solithromycin displays excellent in vitro activity against a broad spectrum of Gram-positive respiratory tract pathogens, including macrolide-resistant strains.


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