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Sodium 4-phenylbutyrate

based on 3 citations in multiple journalsSodium 4-phenylbutyrate34.1 4
A HDAC inhibitor
Catalog #: 1608
SKU-Size Size Price Qty
1608-100 100 mg
1608-1000 1 g
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Product Details

Alternate Name 4-Phenylbutyric acid, sodium salt, Sodium phenylbutyrate, 4-PB
Appearance White to yellowish solid
CAS # 1716-12-7
Molecular Formula C₁₀H₁₁O₂ . Na
Molecular Weight 186.2
Purity ≥99% by HPLC
Solubility DMSO ( 100 mM) and H₂O (100 mM)
SMILES C1=CC=C(C=C1)CCCC(=O)[O-].[Na+]
InChi InChI=1S/C10H12O2.Na/c11-10(12)8-4-7-9-5-2-1-3-6-9;/h1-3,5-6H,4,7-8H2,(H,11,12);/q;+1/p-1
PubChem CID 5258
MDL Number MFCD00800247
Handling Protect from air and moisture
Storage Conditions -20°C
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.


Inhibitor of histone deacetylase (HDAC). Anti-neoplastic agent and transcriptional regulator. Also acts as an inducer of tumor cytostasis and differentiation.

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Chen et al., Endoplasmic Reticulum Stress and Store-Operated Calcium Entry Contribute to Usnic Acid-Induced Toxicity in Hepatic Cells. Toxicol. Sci., Jul 2015; 146: 116 - 126.
Gautherot, J. et al., Effects of Cellular, Chemical, and Pharmacological Chaperones on the Rescue of a Trafficking-defective Mutant of the ATP-binding Cassette Transporter Proteins ABCB1/ABCB4,  J. Biol. Chem., Feb 2012; 287: 5070 - 5078.
Lijie Ma  et al., Molecular and Cellular Effects of Tamm-Horsfall Protein Mutations and Their Rescue by Chemical Chaperones, J. Biol. Chem., Jan 2012; 287: 1290 - 1305.
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