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SOCS1 Antibody

Catalog #: 3861
SKU-Size Size Price Qty
3861-30T 30 µg
$89.00
3861-100 100 µg
$245.00
More Sizes Get Quote

Product Details

Antibody Target SOCS1
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen Synthetic peptide surrounding amino acid 196 of rat SOCS1
Accession # Q9QX78
Gene ID 252971
Appearance Colorless liquid
Concentration 0.5 mg/ml
Formulation 100 µg (0.5 mg/ml) affinity purified rabbit polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.
Purification Affinity purified
Species Reactivity Human
Application Western blot
Application & Usage Western blotting (0.5-4 µg/ml). However, the optimal conditions should be determined individually. Other applications have not been tested. The antibody detects ~30 kDa SOCS1 on SDS-PAGE immunoblots. Blocking peptide (Cat.# 3861BP-50) is available separat
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

The Suppressor of cytokine signaling (SOCS) and cytokine-inducible SH2 proteins are a family of intracellular proteins that regulate responses to cytokines. SOCS1 suppresses dendritic cell and T cell hyperactivation in response to cytokine signaling by inhibiting the JAK tyrosine kinase. JAK tyrosine kinase activity is important for type I and II cytokine receptors to initiate signaling, and its activity is inhibited by direct binding of SOCS1 to the catalytic domain of the kinase. SOCS1 also has E3 ubiquitin protein ligase activity that results in the polyubiquitination of its target proteins and subsequent degradation by the proteosome.


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