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SNX-2112

Aotent heat-shock protein 90 (Hsp90) inhibitor with potential antineoplastic activity
Catalog #: B2211

In stock

SKU-Size Size Price Qty
B2211-5 5 mg
$125.00
B2211-25 25 mg
$495.00
More Sizes Get Quote

Product Details

Alternate Name 2-[(trans-4-Hydroxycyclohexyl)amino]-4-[4,5,6,7-tetrahydro-6,6-dimethyl-4-oxo-3-(trifluoromethyl)-1H-indazol-1-yl]benzamide; PF-04928473
Appearance Crystalline solid
CAS # 908112-43-6
Molecular Formula C₂₃H₂₇F₃N₄O₃
Molecular Weight 464.48
Purity ≥98% by HPLC
Solubility DMSO (>50 mg/ml)
SMILES CC1(CC2=C(C(=O)C1)C(=NN2C3=CC(=C(C=C3)C(=O)N)NC4CCC(CC4)O)C(F)(F)F)C
InChi InChI=1S/C23H27F3N4O3/c1-22(2)10-17-19(18(32)11-22)20(23(24,25)26)29-30(17)13-5-8-15(21(27)33)16(9-13)28-12-3-6-14(31)7-4-12/h5,8-9,12,14,28,31H,3-4,6-7,10-11H2,1-2H3,(H2,27,33)
InChi Key ZFVRYNYOPQZKDG-UHFFFAOYSA-N
PubChem CID 24772860
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

SNX-2112 is a potent heat-shock protein 90 (Hsp90) inhibitor with potential antineoplastic activity. SNX-2112 selectively accumulates in tumors compared to normal tissues and binds to the N-terminal adenosine triphosphate binding site of Hsp90, inhibiting its activity. This results in the proteasomal degradation of oncogenic client proteins, which prevents signaling through these client proteins, induces apoptosis and inhibits tumor cell proliferation.


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